cees dekker - An Overview
cees dekker - An Overview
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Nanotechnology offers a range of options to lead to biology. Below I'll current illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is used to examine the biophysics of solitary molecules and cells. I will current some examples from our lab:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Within the very same time, the group of Paul McEuen, who was then centered with the University of California, Berkeley, showed very similar benefits on ropes of bundled nanotubes. With regards to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified making use of scanning tunnelling spectroscopy experiments.
I'm able to rarely consider how I, for a geneticist, would have the capacity to study elementary physics, let alone compete at the best. How did you go about this?
We build stage-of-treatment diagnostics take a look at of neglected tropical conditions inside of resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in system fluids.
While in the a long time subsequent these discoveries, my study interests shifted to biophysics and nanobiology, And that i turned considerably less associated with the development of nanotube electronics. The main target of numerous researchers in the field also shifted to graphene (wherever, funnily ample, the initial graphene ribbons had been called ‘nanotubes that happen to be Minimize open together their size’) right after the discovery of The 2-dimensional content in 2004.
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his analysis has focused on finding out cell division with microbes on chip, when his supreme interest is during the route of recognizing artificial cells.
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Quite cool, but that wasn’t actually where by my interest lay. I wished to pioneer And that i experienced the ceesdekker.net feeling that was no more probable, because the most exciting essential insights experienced currently been uncovered. But my discipline experienced developed several interesting new applications to measure personal molecules. I decided which i wished to implement this to biology, to have a look at it from the physical point of view.’
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for your new Luttinger description of interacting electrons in nanotubes
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA repair complexes; and 1st drive measurements on the DNA molecule in a very nanopore
‘I am driven by ponder and thoughts. On a fabric level I come across responses in physics, but I encounter my deepest contentment with God. That faith also drives my science and how I handle people.